Christina Applegate has reportedly been hospitalized amid her ongoing battle with multiple sclerosis (MS).
Sources told TMZ that the 54-year-old actress was admitted into a hospital late last month, but a reason has yet to be revealed.
Applegate’s representative told the Daily Mail, ‘I have no comment on whether she is in the hospital or what her medical treatments are.
‘She’s had a long history of complicated medical conditions that she has been refreshingly open about, as evidenced in her memoir and on her podcast.’
The Married… With Children actress announced her diagnosis with the chronic autoimmune disease in 2021.
And a few months earlier in February, Applegate heartbrokenly shared that she is mainly confined to her bed due to her MS battle.
During an interview with People at the time, the star explained how the pain has largely kept her in bed.
However, she will make the effort to leave her bedroom for her teenage daughter Sadie – such as taking her to school.
‘I want to take her; it’s my favorite thing to do. It’s the only time we have together by ourselves,’ the actress told the outlet.
‘I tell myself, “Just get her there safely and get home so you can get back into bed.” And that’s what I do.’
Applegate further expressed, ‘My life isn’t wrapped up with a bow. People’s lives, sorry for lack of a better term, f***ing suck sometimes. So I’m being as honest and raw as I possibly can.’
Multiple sclerosis occurs when ‘the immune system attacks the protective sheath that covers nerve fibers, known as myelin,’ per Mayo Clinic.
The disease ‘can cause numbness, weakness, trouble walking, vision changes and other symptoms.’
The Dead To Me actress also reflected on her MS battle in an excerpt of her 2026 memoir You With The Sad Eyes that was published in The Guardian in March.
‘One of the worst side-effects of the illness is the exhaustion,’ Applegate candidly wrote.
‘It feels as though I’ve been on a three‑day sleepless bender – and that’s how I feel after a good night’s sleep. Hence all the time I spend on and in bed, snuggled up against my heating pad.’
She continued, ‘On the back of that diagnosis and the symptoms I face, I no longer care what I say or how I come across or how it makes anyone feel.
‘I don’t have patience for bulls*** any more, for things that are meaningless or merely “extra.”‘
Applegate shared the news of her MS diagnosis on social media in August 2021.
‘Hi friends. A few months ago I was diagnosed with MS. It’s been a strange journey. But I have been so supported by people that I know who also have this condition,’ she had explained at the time.
‘It’s been a touch road. But as we all know, the road keeps going,’ the star added, showing her positivity towards her health condition.
During an episode of her MeSsy podcast last year, the actress revealed that she had been hospitalized multiple times amid her MS battle.
‘For three years since I was diagnosed, I’ve been in the hospital upwards of 30 times,’ she told her co-host Jamie-Lynn Sigler – who is also battling the same disease.
‘That is unimaginable, okay? They’ve done every test known to man on me, put so much radiation into my body from CT scans to everything else.’
And she recorded an episode of the podcast from her hospital bed in August 2025 while being treated for a kidney infection.
She went to the hospital due to feeling unwell after a family trip to Europe.
‘I’m like, I wanna be admitted,’ Applegate explained. ‘I’m staying here because I want answers. I want every test that you can possibly think of or ones that you haven’t even thought of, and I want them done.’
The actress remembered waking up to severe pain in her right side that left her ‘screaming.’
After undergoing an emergency CT scan, it was revealed that she had a kidney infection.
When it came to penning her memoir – which was released on March 3 – Applegate previously shared that she made the decision to pen the book when she was ‘forced to slow down.’
‘I’ve had a career in TV and film since I was 3 years old, and I loved it. But with MS, all the things I thought were important shifted,’ the Emmy-nominated actress said began in a statement, per People.
‘For a long time, it felt impossible to find the meaning in everything I’ve been through, but for the first time in my life I’ve been able to stop and reflect.’
The star also admitted that it was ‘scary’ to ‘to tell it all’ in her candid memoir.
‘But no matter how dark it gets, I wrote this because I truly believe that books can make people feel less alone.’
